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A Study of Cardiac Autonomic Functions in Patients with Chronic Stable Angina Undergoing Percutaneous Coronary

Waqas Alauddin1, Meenakshi Chaswal2, Musharaf Bashir3

  • 1Hinduhridaysamrat Balasaheb Thackarey Medical College, Dr. Rustom Narsi Cooper Hospital, Juhu, Mumbai, India.

Medeniyet Medical Journal
|July 9, 2021
PubMed

Insights

Percutaneous coronary intervention (PCI) significantly improved cardiac autonomic functions in patients with coronary slow flow (CSF) as measured by heart rate variability (HRV). These findings suggest HRV can help assess disease progression in CSF patients.

Area of Science:

  • Cardiology
  • Autonomic Neuroscience
  • Medical Technology

Background:

  • Coronary slow flow (CSF) is a condition affecting coronary artery blood flow.
  • Cardiac autonomic dysfunction is often observed in patients with cardiovascular diseases.
  • Heart rate variability (HRV) is a non-invasive tool to assess autonomic nervous system activity.

Purpose of the Study:

  • To evaluate cardiac autonomic functions in patients with coronary slow flow (CSF) before and after percutaneous coronary intervention (PCI).
  • To assess the impact of PCI on heart rate variability (HRV) parameters in CSA patients.

Main Methods:

  • Thirty patients diagnosed with CSA were enrolled from cardiology outpatient clinics.
  • Heart rate variability (HRV) parameters including LF, HF, LF:HF ratio, SDNN, RMSSD, total power, and pNN50 were measured before and after PCI.
  • Data were analyzed using SPSS version 21.0.

Main Results:

  • Significant improvements were observed in SDNN, RMSSD, and pNN50 post-PCI compared to pre-PCI values.
  • Both LF and HF power, as well as total power, showed significant increases after PCI.
  • The LF:HF ratio did not show a statistically significant difference between pre-PCI and post-PCI measurements.

Conclusions:

  • PCI leads to significant improvements in resting cardiovascular parameters and autonomic tone in CSA patients.
  • HRV analysis indicates increased parasympathetic and sympathetic reactivity following revascularization in CSA patients.
  • HRV is recommended as a non-invasive method for risk stratification in disease progression for CSA patients.
Abstract

Keywords:
Sudden cardiac deathautonomic dysfunctionchronic stable anginaheart rate variabilitypercutaneous coronary intervention

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