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Current Status of Pediatric Formulations for Chronic and Acute Children' Diseases: Applications and Future

Panoraia Siafaka1, Esra Ipekci2, Emre Şefik Caglar2

  • 1Aristotle University of Thessaloniki, Department of Chemistry, Thessaloniki, Greece.

Medeniyet Medical Journal
|July 9, 2021
PubMed

Insights

Developing pediatric medications is challenging due to children's unique physiology and formulation needs. This review summarizes child-friendly drug delivery systems to improve pediatric patient care and safety.

Area of Science:

  • Pediatric Pharmacology
  • Drug Delivery Systems
  • Pharmaceutical Sciences

Background:

  • Children face unique health challenges, including rare illnesses.
  • Pediatric drug development is complex due to difficulties with standard dosage forms (e.g., tablets) and unlicensed medications.
  • Pediatric dosing differs significantly from adults, influenced by age-related variations in drug absorption, distribution, metabolism, and elimination (ADME).

Purpose of the Study:

  • To review current drug formulations for pediatric patients.
  • To summarize approaches for developing child-friendly drug delivery systems.
  • To aid professionals in designing more efficient and safer pediatric medications.

Main Methods:

  • Literature review of existing pediatric formulations.
  • Summary of therapeutic approaches for pediatric drug delivery.
  • Analysis of challenges in pediatric medication administration.

Main Results:

  • Various formulations like liquid dosage forms and flexible capsules are used for pediatric patients.
  • Children's sensitivity to taste and smell impacts medication adherence.
  • Infants are at higher risk for adverse drug events from adult medications.

Conclusions:

  • Effective pediatric formulations require consideration of age-specific ADME and patient acceptance.
  • Development of child-friendly drug delivery systems is crucial for improving therapeutic outcomes and safety in children.
  • This review provides insights for professionals aiming to create better pediatric drug formulations.

Keywords:
Pediatric diseaseschildrendrug delivery systemsinfantspediatric formulationspharmaceutical technology

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