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In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
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Aptamers isolated against mosquito-borne pathogens.

Tholasi Nadhan Navien1, Tzi Shien Yeoh1, Andrew Anna1,2

  • 1Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Penang, Malaysia.

World Journal of Microbiology & Biotechnology
|July 9, 2021
PubMed
Summary

Aptamers, a novel diagnostic tool, show promise in combating mosquito-borne diseases. These DNA/RNA molecules offer superior specificity and affinity compared to traditional antibodies, aiding in disease detection and treatment.

Keywords:
AptamerDiseaseMosquitoPathogenSELEX

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Area of Science:

  • Molecular biology
  • Infectious diseases
  • Biotechnology

Background:

  • Mosquito-borne diseases pose a significant global health threat, with rising morbidity and mortality.
  • Current diagnostic tools, particularly antibody-based assays, have limitations contributing to disease spread.
  • Aptamers offer a promising alternative to antibodies for molecular recognition in diagnostics.

Purpose of the Study:

  • To provide a comprehensive overview of aptamers developed against mosquito-borne pathogens.
  • To highlight the characteristics and applications of these aptamers in diagnostics and therapeutics.
  • To emphasize the potential of aptamers in addressing the limitations of current diagnostic methods.

Main Methods:

  • Systematic literature review of aptamers developed against mosquito-borne pathogens.
  • Analysis of aptamer characteristics, including binding affinity and specificity.
  • Evaluation of aptamer applications in diagnostic and therapeutic strategies.

Main Results:

  • Numerous aptamers have been successfully developed against various mosquito-borne agents, including Dengue virus, Zika virus, and Plasmodium parasites.
  • Aptamers demonstrate high binding affinity and specificity, outperforming traditional antibody-based methods.
  • These aptamers show potential for diverse applications, from diagnostics to therapeutics.

Conclusions:

  • Aptamers represent a superior alternative to antibodies for the detection and potential treatment of mosquito-borne diseases.
  • The development of aptamer-based tools can significantly improve diagnostic accuracy and public health outcomes.
  • Further research into aptamer technology is crucial for advancing the fight against infectious diseases.