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Related Experiment Videos

Pulmonary tuberculosis in corticosteroid-treated asthmatics.

R L Cowie1, L M King

  • 1Department of Medicine, Ernest Oppenheimer Hospital, Welkom, OFS.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|December 19, 1987
PubMed
Summary

Long-term systemic corticosteroid therapy did not significantly increase tuberculosis risk in asthmatic men. The study suggests continuing necessary corticosteroid treatment for asthma, even in high-prevalence populations.

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Tuberculosis in Calgary, Canada, 1995-2002: site of disease and drug susceptibility.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2005

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Pharmacology

Background:

  • Tuberculosis (TB) is a significant public health concern, particularly in high-prevalence areas.
  • Asthma management often involves long-term systemic corticosteroid use.
  • The potential impact of corticosteroids on TB risk requires careful evaluation.

Purpose of the Study:

  • To investigate the association between long-term systemic corticosteroid therapy and the risk of developing pulmonary tuberculosis in asthmatic men.
  • To determine if prophylactic treatment with isoniazid is warranted for asthmatic patients on long-term corticosteroids.

Main Methods:

  • A cohort study was conducted in a population with a high prevalence of tuberculosis.
  • Asthmatic men receiving long-term systemic corticosteroid therapy were monitored for the development of pulmonary tuberculosis.

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  • Statistical analysis was used to assess the risk attributable to corticosteroid use.

    • Main Results:

    • No statistically significant increased risk of pulmonary tuberculosis was found in asthmatic men using long-term systemic corticosteroids.
    • A slight trend towards increased TB risk was observed, but the attributable risk was minimal.
    • The findings do not support routine isoniazid prophylaxis in this patient group.

    Conclusions:

    • Long-term systemic corticosteroid therapy is unlikely to pose a significant risk for developing pulmonary tuberculosis in asthmatic men.
    • Necessary corticosteroid treatment for asthma should not be withheld based on concerns about TB risk.
    • Further research may be needed to fully elucidate the complex relationship between corticosteroids and TB in diverse populations.