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Is time ready for combination therapy at diagnosis of type 2 diabetes?

Francesco Prattichizzo1, Antonio Ceriello1

  • 1IRCCS MultiMedica, Milan, Italy.

Diabetes/Metabolism Research and Reviews
|July 9, 2021
PubMed

Insights

Newer diabetes drugs like SGLT-2 inhibitors show cardio-renal benefits for type 2 diabetes (T2D) patients, even without prior cardiovascular disease (CVD). A combination therapy with metformin may be optimal for newly diagnosed T2D.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • GLP-1 receptor agonists and SGLT-2 inhibitors demonstrate significant cardio-renal benefits in type 2 diabetes (T2D) patients with cardiovascular diseases (CVD).
  • Emerging data suggest these benefits extend to T2D patients without pre-existing CVD.
  • The efficacy of these novel agents is not altered by background therapies.
Keywords:
GLP-1 receptor agonistsSGLT-2 inhibitorscardiovascular diseasesmetformintreatment algorithmtype 2 diabetes

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