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The structural connectome constrains fast brain dynamics.

Pierpaolo Sorrentino1,2,3,4, Caio Seguin5, Rosaria Rucco2,3

  • 1Aix-Marseille University, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.

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|July 9, 2021
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Summary
This summary is machine-generated.

The human brain's structural connections influence its rapid neural activity patterns. This study links the brain's structural connectome to the spreading of neuronal avalanches, revealing how physical brain wiring shapes dynamic activity.

Keywords:
brain dynamicsbrain networkscomputational biologyhumanmagnetoencephalographysystems biologysystems neuroscience

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Area of Science:

  • Neuroscience
  • Brain dynamics
  • Connectomics

Background:

  • Brain activity at rest exhibits complex, dynamic spatio-temporal patterns.
  • The human connectome, comprising structural connections, is thought to constrain these neural dynamics.

Purpose of the Study:

  • To quantify how structural brain connections constrain fast neural dynamics.
  • To investigate the relationship between the structural connectome and millisecond-scale brain activity patterns.

Main Methods:

  • Utilized magnetoencephalography (MEG) for source-reconstructed brain activity.
  • Analyzed spatio-temporal unfolding of whole-brain activity at the millisecond scale.
  • Inferred structural connections using diffusion MRI tractography.

Main Results:

  • Found a significant association between structural connectivity strengths and the probability of transitions in neural activity (r = 0.37, p<0.0001).
  • Demonstrated that the structural connectome relates to and likely affects the rapid spreading of neuronal avalanches.

Conclusions:

  • The study provides evidence that the brain's structural wiring influences its rapid neural dynamics.
  • Findings open new research avenues for understanding the structure-function relationship in the human brain.