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Updated: Oct 29, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Aqueous choline amino acid deep eutectic solvents
Shurui Miao1, Haihui Joy Jiang1, Silvia Imberti2
1School of Chemistry and Sydney Nano Institute, The University of Sydney, NSW 2006, Australia.
Abstract:
We have investigated the structure and phase behavior of biocompatible, aqueous deep eutectic solvents by combining choline acetate, hydrogen aspartate, and aspartate amino acid salts with water as the sole molecular hydrogen bond donor. Using contrast-variation neutron diffraction, interpreted via computational modeling, we show how the interplay between anion structure and water content affects the hydrogen bond network structure in the liquid, which, in turn, influences the eutectic composition and temperature. These mixtures expand the current range choline amino acid ionic liquids under investigation for biomass processing applications to include higher melting point salts and also explain how the ionic liquids retain their desirable properties in aqueous solution.
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