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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Oct 29, 2025

A Permanent Window for Investigating Cancer Metastasis to the Lung

A Permanent Window for Investigating Cancer Metastasis to the Lung

Published on: July 1, 2021

Arresting metastasis within the microcirculation.

Angelos Varotsos Vrynas¹, Julia Perea Paizal^1,2, Chris Bakal²

¹Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.

Clinical & Experimental Metastasis

|July 9, 2021

Summary

This summary is machine-generated.

The behavior of circulating tumor cells (CTCs) in tiny blood vessels is unclear. Understanding how immune cells and platelets affect CTCs is key to metastasis research.

Keywords:

Biomechanics Cancer Circulating tumour cells Immune cells Metastasis Microvasculature Platelets

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Last Updated: Oct 29, 2025

A Permanent Window for Investigating Cancer Metastasis to the Lung

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Published on: July 1, 2021

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

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Published on: May 14, 2019

Automated Measurement of Microcirculatory Blood Flow Velocity in Pulmonary Metastases of Rats

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Published on: November 30, 2014

Area of Science:

Oncology
Cell Biology
Physiology

Background:

The behavior of circulating tumor cells (CTCs) within the microcirculation is not well understood.
Evidence suggests biomechanical adaptations and interactions with blood components influence CTCs' metastatic journey.
Capillary beds are critical sites where these interactions occur.

Purpose of the Study:

To investigate the complex behavior of circulating tumor cells in the microcirculation.
To elucidate the impact of blood components like immune cells and platelets on CTC survival and metastasis.
To advance the understanding of the microcirculation's role in cancer metastasis.

Main Methods:

This study focuses on the theoretical and evidence-based analysis of CTC behavior.
Utilizes existing literature and biomechanical principles to model interactions.
No new experimental data was generated; it's a review and synthesis of current knowledge.

Main Results:

Circulating tumor cells face complex challenges in the microcirculation.
Interactions with immune cells and platelets significantly affect CTC survival and metastatic potential.
The microenvironment within capillary beds plays a crucial role in metastasis.

Conclusions:

Understanding CTC interactions with blood components in microcirculation is vital.
Further research into these mediators will enhance our knowledge of metastasis.
This knowledge is critical for developing new therapeutic strategies targeting metastasis.