Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis in E. coli01:27

Chemotaxis in E. coli

286
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
286

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the Current ATTR-CM Treatment Landscape via a Mathematical Model of TTR Dissociation and Amyloid Formation.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Genome modelling and design across all domains of life with Evo 2.

Nature·2026
Same author

Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces.

bioRxiv : the preprint server for biology·2026
Same author

The EcoCyc database (2025).

EcoSal Plus·2025
Same author

Integrating multiplexed imaging and multiscale modeling identifies tumor phenotype conversion as a critical component of therapeutic T cell efficacy.

Cell systems·2024
Same author

Cross-evaluation of E. coli's operon structures via a whole-cell model suggests alternative cellular benefits for low- versus high-expressing operons.

Cell systems·2024
Same journal

A history of <i>EcoSal Plus</i>.

EcoSal Plus·2025
Same journal

Transcriptional reprogramming by bacteriophage T4: turning the host transcriptional machinery to the dark side.

EcoSal Plus·2025
Same journal

Bacteriophage T4 genome packaging: mechanism and application.

EcoSal Plus·2025
Same journal

The bacteriophage T4 homologous recombination system: mechanism, applications, conservation, and environmental significance.

EcoSal Plus·2025
Same journal

The bacteriophage T4 replisome: a model system for understanding DNA replication mechanisms.

EcoSal Plus·2025
Same journal

Biology of host-dependent restriction-modification in prokaryotes.

EcoSal Plus·2025
See all related articles

Related Experiment Video

Updated: Oct 29, 2025

Escherichia coli-Based Cell-Free Protein Synthesis: Protocols for a robust, flexible, and accessible platform technology
09:45

Escherichia coli-Based Cell-Free Protein Synthesis: Protocols for a robust, flexible, and accessible platform technology

Published on: February 25, 2019

36.3K

The E. coli Whole-Cell Modeling Project.

Gwanggyu Sun1, Travis A Ahn-Horst1, Markus W Covert1

  • 1Department of Bioengineering, Stanford University, Stanford, California, USA.

Ecosal Plus
|July 9, 2021
PubMed
Summary
This summary is machine-generated.

The Escherichia coli whole-cell modeling project is building a detailed computational model to understand cell behavior. Community involvement will accelerate discoveries by improving the model with more data.

Keywords:
computational modelingmicrobiologywhole-cell modeling

More Related Videos

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization
06:33

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization

Published on: October 29, 2019

10.3K
Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

46.6K

Related Experiment Videos

Last Updated: Oct 29, 2025

Escherichia coli-Based Cell-Free Protein Synthesis: Protocols for a robust, flexible, and accessible platform technology
09:45

Escherichia coli-Based Cell-Free Protein Synthesis: Protocols for a robust, flexible, and accessible platform technology

Published on: February 25, 2019

36.3K
Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization
06:33

Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization

Published on: October 29, 2019

10.3K
Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

46.6K

Area of Science:

  • Computational biology
  • Systems biology
  • Microbial genomics

Background:

  • Escherichia coli is a crucial model organism for biological research.
  • Understanding cellular mechanisms requires comprehensive computational tools.
  • Previous models lacked the detail to fully predict cellular behavior.

Purpose of the Study:

  • To develop a highly detailed computational model of an Escherichia coli cell.
  • To enhance the understanding and prediction of E. coli's physiological behavior.
  • To foster community engagement for model improvement and data integration.

Main Methods:

  • Developing a computational framework for whole-cell modeling.
  • Integrating functional genomic data into the model.
  • Utilizing deep curation to incorporate diverse datasets.

Main Results:

  • The current model incorporates functions for 43% of characterized E. coli genes.
  • Ongoing efforts are expanding the model's scope and accuracy.
  • The model serves as a platform for verifying physiological behavior and generating hypotheses.

Conclusions:

  • The detailed E. coli whole-cell model is a valuable resource for the research community.
  • Increased community involvement will accelerate the model's development and utility.
  • The model facilitates efficient experimental design and data evaluation.