Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study

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Jana J Anderson1, Frederick K Ho1, Claire L Niedzwiedz1

  • 1Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Journal of Thrombosis and Haemostasis : JTH
|July 9, 2021
PubMed

Insights

A remote history of venous thromboembolism (VTE) increases the risk of severe COVID-19, particularly in men. These findings suggest including past VTE in COVID-19 risk assessments.

Area of Science:

  • Epidemiology
  • Public Health
  • Internal Medicine

Background:

  • Venous thromboembolism (VTE) is a known complication of COVID-19.
  • Existing COVID-19 risk models incorporate VTE history.
  • The impact of remote VTE history (>9 years) on COVID-19 risk is not well understood.

Purpose of the Study:

  • To investigate the association between remote VTE history and COVID-19 severity.
  • To determine if this association is independent of other risk factors.

Main Methods:

  • A cohort study using UK Biobank participants (2006-2010).
  • Linking baseline VTE history to COVID-19 outcomes (testing, hospitalization, death).
  • Poisson regression models adjusted for confounders.

Main Results:

  • Remote VTE history was associated with increased risk of nonfatal community-acquired, nonfatal hospitalized, and severe COVID-19.
  • The association was stronger in men than in women.
  • Adjustments were made for sociodemographic, lifestyle, and comorbid factors.

Conclusions:

  • Remote VTE history should be considered for COVID-19 risk prediction.
  • Sex-specific risk scores may be beneficial for managing COVID-19 risk.
Abstract

Keywords:
COVID-19 severityDVTPESARS-CoV2 infectionvenous thromboembolism

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