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Differences in effect between nomifensine and nortriptyline.

W Pöldinger, G Gammel

International Pharmacopsychiatry

|January 1, 1978

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This study found nomifensine effective for treating retarded depressions, showing distinct antidepressive and activating effects comparable to nortriptyline. Nomifensine may offer better outcomes, especially for patients who drop out of treatment.

Area of Science:

Psychiatry
Clinical Pharmacology

Background:

Retarded depression is a subtype of depression characterized by psychomotor retardation.
Antidepressant medications are a cornerstone of treatment for various depressive disorders.

Purpose of the Study:

To compare the efficacy and effects of nomifensine and nortriptyline in outpatients with retarded depressions.
To evaluate the antidepressive and activating properties of nomifensine.

Main Methods:

A double-blind, randomized study involving 40 outpatients diagnosed with retarded depression.
Patients were assigned to receive either nomifensine or nortriptyline (150 mg/day) for 21 days.
Depression symptoms were assessed using a standardized depression scale.

Main Results:

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Both nomifensine and nortriptyline groups showed significant improvement in psychic symptoms.
No statistically significant difference was observed between the two treatment groups overall.
Preliminary data from dropouts suggested a potentially better effect profile for nomifensine.

Conclusions:

Nomifensine is a suitable treatment option for patients suffering from retarded depressions.
The study highlights nomifensine's antidepressive and activating effects in this patient population.
Further investigation into nomifensine's efficacy, particularly in patient subgroups or those with treatment attrition, may be warranted.