Pitfalls on PET/CT Due to Artifacts and Instrumentation
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT.
Seminars in Nuclear Medicine
|July 10, 2021
Summary
Positron Emission Tomography/Computed Tomography (PET/CT) offers improved accuracy but presents unique pitfalls. This review examines PET/CT instrumentation limitations and artifacts, discussing solutions for enhanced image quality and quantitative accuracy.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Radiology
Background:
- Positron Emission Tomography/Computed Tomography (PET/CT) is a widely adopted imaging modality in clinical practice.
- While PET/CT enhances diagnostic accuracy and patient throughput compared to PET-only scanners, it introduces specific limitations and artifacts.
- These issues can impact image appearance and the quantitative accuracy of PET data.
Purpose of the Study:
- To provide an overview of potential influences of PET/CT instrumentation limitations and integration artifacts on image quality.
- To discuss proposed approaches for addressing these limitations and minimizing artifacts.
- To highlight current challenges in the clinical application of these solutions.
Main Methods:
- Literature review focusing on PET/CT instrumentation and artifacts.
- Analysis of how CT integration affects PET image appearance and quantitative accuracy.
- Examination of proposed mitigation strategies and their clinical applicability.
Main Results:
- PET/CT instrumentation and integration artifacts can significantly affect PET image appearance and quantitative accuracy.
- Various approaches exist to mitigate these issues, though clinical implementation faces challenges.
- The CT component's role in attenuation and scatter correction is crucial.
Conclusions:
- Understanding and addressing PET/CT limitations and artifacts is essential for reliable diagnostic interpretation.
- Continued research and development are needed to overcome current challenges in artifact reduction and quantitative accuracy.
- Optimizing PET/CT protocols is key to maximizing its clinical benefits.
Related Concept Videos
01:10Computed Tomography
7.3K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.3K
01:28Imaging Studies for Cardiovascular System V: CT
105
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
105
01:29Positron Emission Tomography
6.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.3K
01:27Imaging Studies III: Computed Tomography
103
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
103
01:20Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
738
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
738
01:17Ultrasonography
6.8K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
During an ultrasonography procedure, a handheld device called...
6.8K