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Updated: Oct 29, 2025

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Computed Tomography Techniques, Protocols, Advancements, and Future Directions in Liver Diseases
Naveen M Kulkarni1, Alice Fung2, Avinash R Kambadakone3
1Department of Radiology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA.
Computed tomography (CT) is essential for diagnosing liver disease. This review covers current CT techniques, advancements like wide-detector and multienergy scanning, and optimizing imaging for hepatocellular carcinoma detection.
Area of Science:
- Radiology
- Medical Imaging
Background:
- Computed tomography (CT) is the primary imaging modality for evaluating liver disease.
- Accurate CT protocols are crucial for effective patient management.
Purpose of the Study:
- To review current liver CT techniques and protocols.
- To highlight recent CT advancements impacting clinical practice.
- To emphasize optimizing imaging for hepatocellular carcinoma evaluation.
Main Methods:
- Review of clinical practice CT techniques for liver disease.
- Discussion of CT advancements: wide-detector CT, dose optimization, multienergy scanning.
- Focus on optimizing the late arterial phase of enhancement.
Main Results:
- Wide-detector CT, dose optimization, and multienergy scanning offer clinical benefits.
- Optimized late arterial phase imaging is critical for hepatocellular carcinoma detection.
- Emerging CT techniques show promise for future liver disease assessment.
Conclusions:
- Current CT techniques and recent advancements improve liver disease diagnosis.
- Optimized contrast enhancement protocols are vital for detecting hepatocellular carcinoma.
- Future CT technologies will further enhance liver imaging capabilities.
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