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Related Experiment Video

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Hepatocarcinogenesis: Radiology-Pathology Correlation.

Alice Fung1, Krishna P Shanbhogue2, Myles T Taffel2

  • 1Department of Diagnostic Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-340, Portland, OR 97239, USA.

Magnetic Resonance Imaging Clinics of North America
|July 10, 2021
PubMed
Summary

Hepatocellular carcinoma develops through hepatocarcinogenesis, a multistep process in chronic liver disease. This review highlights imaging findings of pathological changes from nodules to liver cancer.

Keywords:
Dysplastic noduleHepatocarcinogenesisHepatocellular carcinomaLiverLiver reporting & data system (LI-RADS)

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Area of Science:

  • Hepatology
  • Oncology
  • Radiology

Background:

  • Chronic liver disease is a major risk factor for hepatocellular carcinoma.
  • Hepatocellular carcinoma develops through a complex, multistep process known as hepatocarcinogenesis.
  • Understanding the stages of hepatocarcinogenesis is crucial for early detection and management.

Purpose of the Study:

  • To review the causes contributing to hepatocarcinogenesis.
  • To emphasize the imaging manifestations of pathological changes during hepatocarcinogenesis.
  • To correlate imaging findings with different stages of liver disease progression.

Main Methods:

  • Literature review of studies on hepatocarcinogenesis.
  • Analysis of imaging findings in various stages of liver disease.
  • Correlation of pathological changes with radiological features.

Main Results:

  • Hepatocarcinogenesis involves distinct pathological changes, including regenerative nodules, dysplastic nodules, and eventually hepatocellular carcinoma.
  • Imaging plays a critical role in identifying these pathological changes at different stages.
  • Specific imaging features are associated with each stage, aiding in diagnosis.

Conclusions:

  • Hepatocellular carcinoma development is a progressive process driven by chronic liver disease.
  • Radiological imaging is essential for monitoring disease progression and detecting malignancy.
  • Early identification of imaging abnormalities in hepatocarcinogenesis can improve patient outcomes.