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The stability of 5,6-dihydrofluorouracil in plasma and the consequences for its analysis
N van den Bosch1, O Driessen, E A van der Velde
1Department of Pharmacology, University of Leiden, The Netherlands.
Abstract:
This study shows that 5,6-dihydrofluorouracil kept in plasma at room temperature deteriorates in time. Preservation is gained by low temperature and low pH of plasma samples. Therefore, plasma samples should be buffered and frozen immediately after being obtained, and thawing should proceed to 5 degrees C only.
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