Related Experiment Video
Updated: Oct 29, 2025

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
MAGUKs are essential, but redundant, in long-term potentiation
Xiumin Chen1, Yuko Fukata2,3, Masaki Fukata2,3
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158.
Abstract:
This study presents evidence that the MAGUK family of synaptic scaffolding proteins plays an essential, but redundant, role in long-term potentiation (LTP). The action of PSD-95, but not that of SAP102, requires the binding to the transsynaptic adhesion protein ADAM22, which is required for nanocolumn stabilization. Based on these and previous results, we propose a two-step process in the recruitment of AMPARs during LTP. First, AMPARs, via TARPs, bind to exposed PSD-95 in the PSD. This alone is not adequate to enhance synaptic transmission. Second, the AMPAR/TARP/PSD-95 complex is stabilized in the nanocolumn by binding to ADAM22. A second, ADAM22-independent pathway is proposed for SAP102.
Related Concept Videos
Long-term Potentiation
Hebbian LTP
LTP can occur when...
Long-term Potentiation
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Long-term Depression
Ligand-Gated Ion Channel Receptor: Gating Mechanism
GPCR Desensitization

