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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long-sought-after mimetics for ortho/meta-substituted arenes

Jin-Xin Zhao1,2, Yu-Xuan Chang1, Chi He1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.

Proceedings of the National Academy of Sciences of the United States of America
|July 10, 2021
PubMed

Keywords:
bioisosteresmedicinal chemistrysynthesis

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