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An intradialytic non-immersive virtual reality exercise programme: a crossover randomized controlled trial.
Francisco J Martínez-Olmos1, Antonia A Gómez-Conesa2, Alicia García-Testal3
1Department of Physiotherapy, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Summary
Intradialytic virtual reality (VR) exercise significantly improved physical function in patients with chronic kidney disease. This non-immersive program enhanced mobility and strength, demonstrating a viable new exercise modality for this population.
Area of Science:
- Nephrology
- Rehabilitation Medicine
- Exercise Physiology
Background:
- Chronic kidney disease (CKD) is associated with significant mortality, disability, and reduced physical function.
- Patients with CKD often experience frailty and poor physical performance, necessitating effective interventions.
- Intradialytic exercise programs aim to improve patient outcomes during dialysis sessions.
Purpose of the Study:
- To evaluate the impact of an intradialytic non-immersive virtual reality (VR) exercise program on the physical function of CKD patients.
- To assess patient adherence to the VR exercise intervention during hemodialysis.
- To determine if VR exercise can mitigate the decline in physical capacity associated with CKD.
Main Methods:
- A 12-week crossover randomized controlled trial involving 56 CKD patients undergoing hemodialysis.
- Participants completed functional capacity evaluations (e.g., 4-m gait speed, SPPB, TUG, OLST, STS, 6MWT) before and after each study period.
- Data analyzed using a two-way repeated-measures ANOVA to compare outcomes between VR exercise and control periods.
Main Results:
- Significant improvements were observed in multiple physical function measures after the VR exercise period compared to the control period.
- Key improvements included increased 4-m gait speed, SPPB scores, OLST duration, STS repetitions, and 6MWT distance.
- Adherence rates to the intradialytic VR exercise program exceeded 70%, with no significant changes in biochemical markers or medications.
Conclusions:
- Intradialytic non-immersive virtual reality exercise is an effective intervention for improving physical function in patients with chronic kidney disease.
- The VR program demonstrates good adherence and offers a promising approach to enhance exercise capacity during dialysis.
- This intervention may help combat frailty and improve the quality of life for individuals with CKD.

