Related Experiment Video
Updated: Oct 29, 2025
14:19
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
28.4K
Catch-down growth in infants born large for gestational age
Rachel K Dunn1, Michael Uhing2, Praveen S Goday3
1Division of Pediatric Gastroenterology, Peyton Manning Children's Hospital, Indianapolis, Indiana, USA.
Summary
Infants born large for gestational age (LGA) without catch-down growth face higher obesity risks. Neonatal nutrition interventions are common in the NICU for these infants, but further research is needed to optimize care.
Area of Science:
- Neonatology
- Pediatric Nutrition
- Growth Monitoring
Background:
- Infants born large for gestational age (LGA) lacking catch-down growth are at increased risk for future obesity.
- Identifying LGA infants in the neonatal intensive care unit (NICU) and understanding growth patterns are crucial for early intervention.
Purpose of the Study:
- To identify term LGA infants admitted to the NICU.
- To document nutrition interventions provided to LGA infants.
- To analyze the relationship between interventions, growth patterns, and length of stay (LOS).
Main Methods:
- Retrospective review of 47 term LGA infants with NICU LOS ≥7 days over 10 years.
- Collection of demographic data, NICU nutrition interventions, and growth pattern data.
- Analysis of catch-down growth, defined as a weight z-score decline of 1.
Main Results:
- 66% of term LGA infants demonstrated catch-down growth at discharge (≥7 days).
- 83% received NICU nutrition interventions, including nasogastric tubes (69%) and formula fortification (51%).
- Infants without catch-down growth and longer LOS (≥14 days) were more likely to receive interventions.
Conclusions:
- Nutrition interventions are frequently administered to LGA infants in the NICU.
- The study underscores the need for further clinical research to guide optimal care strategies for this high-risk population.
- Understanding growth trajectories in LGA infants is essential for predicting and potentially mitigating long-term health risks like obesity.
Related Concept Videos
00:57Population Growth
26.2K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
26.2K
01:10Nature and Nurture
21.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
21.2K
01:15Transcytosis of IgG
3.4K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.4K
01:07Teratogenicity
3.2K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.2K
01:29Oxygen Requirements and Growth Patterns
723
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
723
02:36Cells Coordinate Growth and Proliferation
4.7K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.7K