[Aging markers determined in the oral cavity tissue (literature review).]

Aging is closely related to the decline in the function of many organs. The rate of aging of an organism can vary significantly depending on the lifestyle of a particular person, environmental conditions, hereditary factors, etc. For several decades, markers of aging of the human body, reflecting the work of the main organs and systems, have been generally accepted. At the same time, at the present level of development of medical sciences, the study of the genetic component of aging is relevant. The purpose of the study is to analyze and systematize data related to markers of human aging, determined in substrates of the oral cavity. The search for literary information was carried out on the basis of materials from the RSCI, Pubmed, Cochrane databases. The study included studies of various levels: case-control studies, cohort studies, randomized controlled trials. As a result of the analysis and systematization of literature data, various genetic markers of aging of oral tissues were identified and described: modification of DNA as a whole, changes in the expression of certain genes (over-or under-expressed). Literature review data suggest that exposure to aging predictors may improve treatment and rehabilitation outcomes for dental patients.