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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Updated: Oct 29, 2025

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

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Stem cell therapy in dermatology.

Sujay Khandpur1, Savera Gupta1, D R Gunaabalaji1

  • 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Dermatology, Venereology and Leprology
|July 10, 2021
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers new treatments for various skin conditions by utilizing the regenerative potential of stem cells. Further research is needed to optimize patient selection, treatment protocols, and cost-effectiveness for broader clinical application.

Keywords:
Dermatologypemphigusstem cell therapysystemic lupus erythematosussystemic sclerosis

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Area of Science:

  • Dermatology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Stem cells possess plasticity, differentiating into various cell types, making them promising for therapeutic applications.
  • Stem cells are crucial for skin homeostasis, repair, and regeneration, residing in epidermis, hair follicles, dermis, and adipose tissue.

Purpose of the Study:

  • To review the current applications and therapeutic potential of stem cell therapy in dermatology.
  • To highlight the use of stem cells in treating various dermatological conditions and aesthetic medicine.

Main Methods:

  • Review of existing research on stem cell applications in dermatology.
  • Classification of stem cells based on source and differentiation capacity.

Main Results:

  • Stem cell therapy has shown variable success in treating dermatoses like systemic sclerosis, lupus erythematosus, psoriasis, alopecia, and wound healing.
  • Stem cells are utilized in aesthetic medicine for their regenerative properties.

Conclusions:

  • Stem cell therapy represents a significant advancement towards curative treatments for previously untreatable skin disorders.
  • Further research is essential to address challenges in patient selection, intervention timing, conditioning, post-care, and cost-effectiveness to optimize outcomes.