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FcRn expression in cancer: Mechanistic basis and therapeutic opportunities

Imke Rudnik-Jansen1, Kenneth A Howard1

  • 1Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 10, 2021
PubMed

Insights

New cancer therapeutics require novel cellular targets. The Neonatal Fc Receptor (FcRn) influences drug half-life and presents opportunities for targeted cancer therapies and immune modulation.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • The Neonatal Fc Receptor (FcRn) is crucial for extending the serum half-life of human serum albumin (HSA) and immunoglobulin G (IgG).
  • FcRn-mediated uptake and antigen presentation by epithelial cells and dendritic cells offer novel therapeutic avenues.
  • Altered FcRn expression in solid tumors suggests a role in tumor metabolism and growth.

Purpose of the Study:

  • To review the mechanistic basis of FcRn expression in cancer.
  • To explore the exploitation of FcRn for targeted drug delivery in cancer.
  • To highlight FcRn's role in cancer immunosurveillance and immunotherapy.

Main Methods:

  • Literature review of FcRn's role in cancer biology.
  • Analysis of FcRn expression profiles in various cancers.
  • Discussion of therapeutic strategies targeting FcRn.

Main Results:

  • FcRn influences HSA catabolism and recycling within tumors.
  • FcRn expression patterns vary across different cancer types.
  • FcRn mediates antigen presentation, impacting immunosurveillance.

Conclusions:

  • FcRn is a promising cancer target for drug delivery and immunotherapy.
  • Understanding FcRn's role in cancer pathogenesis is key for developing targeted therapies.
  • Further research is needed to tailor FcRn-targeted drug designs for optimal efficacy and safety.
Keywords:
Albumin-drug designsAntibody-drug designsCancer immunotherapyNeonatal Fc ReceptorTargeted cancer therapyTumour metabolism

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