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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
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Survival in primary hyperparathyroidism over five decades (1965-2010) a population-based retrospective study.
Robert A Wermers1, Marcio L Griebeler2, Prabin Thapa3
1Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Bone
|July 10, 2021
Summary
Survival in primary hyperparathyroidism (PHPT) patients is not different from the general population. However, elevated serum calcium levels increase mortality, which parathyroidectomy can significantly improve.
Area of Science:
- Endocrinology
- Public Health
- Epidemiology
Background:
- Primary hyperparathyroidism (PHPT) is a common endocrine disorder.
- The long-term survival outcomes for PHPT patients in community settings are not well-established.
Purpose of the Study:
- To investigate and update survival rates in a United States community-based population of patients diagnosed with PHPT.
- To identify risk factors associated with mortality in PHPT patients.
Main Methods:
- Retrospective cohort study involving 1139 PHPT patients from Rochester, Minnesota, between 1965 and 2010.
- Survival analysis using Kaplan-Meier method and Cox proportional hazards models.
- Comparison of survival rates against the general white Minnesota population, adjusted for age and gender.
Main Results:
- Overall mortality for the PHPT cohort was not significantly different from the expected rate (RR 0.996, P=0.935).
- Patients with maximum serum calcium levels ≥10.8 mg/dL exhibited increased mortality (RR 1.32, P=0.002).
- Parathyroidectomy did not significantly alter survival in the overall PHPT cohort (RR 1.06, P=0.508), but significantly decreased mortality in those with hypercalcemia (HR 0.47, P<0.001).
Conclusions:
- PHPT patients, as a whole, do not experience reduced survival compared to the general population.
- Elevated serum calcium (≥10.8 mg/dL) is a significant risk factor for increased mortality in PHPT.
- Parathyroidectomy improves survival specifically in PHPT patients with significant hypercalcemia.
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