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Updated: Oct 29, 2025

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
Published on: October 9, 2020
Quantification of magic angle spinning dynamic nuclear polarization NMR spectra
Andrea Bertarello1, Pierrick Berruyer1, Urban Skantze2
1Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Abstract:
Dynamic nuclear polarization (DNP) allows to dramatically enhance the sensitivity of magic angle spinning nuclear magnetic resonance (MAS NMR). DNP experiments usually rely on the detection of low-γ nuclei hyperpolarized from 1H with the use of cross polarization (CP), which assures more efficient signal enhancement. However, CP is usually not quantitative. Here we determine the quantification performance of three different approaches used in MAS NMR, (conventional CP, variable contact time CP, and multiple-contact CP) under DNP conditions, and we show that absolute quantification in MAS DNP NMR is possible, with errors below 10%.
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