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Prevention and Outpatient Treatment of Asthma Exacerbations in Children

Clare S Murray1, Daniel J Jackson2, W Gerald Teague3

  • 1Division of Infection, Immunity, and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

The Journal of Allergy and Clinical Immunology. in Practice
|July 11, 2021
PubMed

Insights

Children with frequent asthma exacerbations face significant challenges. Identifying risk factors and targeted interventions are key to improving their quality of life and reducing healthcare needs.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology

Background:

  • Acute asthma exacerbations significantly impact children's health globally.
  • Frequent exacerbations disproportionately affect healthcare resources and children's quality of life.
  • Poor adherence to controller medications is common in children with frequent exacerbations.

Purpose of the Study:

  • To review modifiable and fixed factors associated with childhood asthma exacerbations.
  • To discuss methods for assessing risk in children prone to exacerbations.
  • To evaluate pharmacological and nonpharmacological interventions for asthma exacerbations.

Main Methods:

  • Literature review of factors influencing asthma exacerbations in children.
  • Analysis of risk assessment strategies for pediatric asthma.
  • Evaluation of current evidence on outpatient treatment for emerging asthma exacerbations.

Main Results:

  • Asthma exacerbations are influenced by genetic, social, comorbid, biological, and environmental factors.
  • Viral infections and other environmental factors are significant triggers.
  • A prior exacerbation is a strong predictor of future events.

Conclusions:

  • Understanding exacerbation predictors is crucial for targeted prevention strategies.
  • Comprehensive assessment and tailored interventions can improve outcomes for children with asthma.
  • Effective outpatient management is essential for emerging asthma exacerbations.

Keywords:
AsthmaChildExacerbation

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