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Updated: Oct 29, 2025

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
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Liposomalization of Oxaliplatin Exacerbates the Non-Liposomal Formulation-Induced Decrease of Sweet Taste Sensitivity

Keisuke Mogi1, Ikumi Kamiya1, Aimi Makino1

  • 1Department of Environmental Biochemistry, Division of Biological Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, JAPAN.

Journal of Pharmaceutical Sciences
|July 11, 2021
PubMed
Summary

PEGylated liposomal oxaliplatin worsens sweet taste loss in rats more than standard oxaliplatin. Cooling the tongue during administration may reduce platinum accumulation in the tongue, preserving taste sensitivity.

Keywords:
CoolingOxaliplatinPEGylated liposomeSweet tasteTaste receptorTaste sensitivity

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Area of Science:

  • Pharmacology
  • Toxicology
  • Neuroscience

Background:

  • Oxaliplatin is a platinum-based chemotherapy drug used to treat various cancers.
  • Oxaliplatin can cause neurotoxicity, including altered taste sensitivity.
  • PEGylated liposomalization of oxaliplatin aims to enhance anticancer efficacy and alter drug distribution.

Purpose of the Study:

  • To investigate if liposomal oxaliplatin alters the sweet taste sensitivity changes induced by oxaliplatin.
  • To determine the effect of liposomalization on platinum accumulation in lingual tissues.
  • To explore potential strategies to mitigate taste alterations during chemotherapy.

Main Methods:

  • Male Sprague-Dawley rats were administered liposomal oxaliplatin (intravenously) or oxaliplatin (intraperitoneally) at 8 mg/kg.
  • Sweet taste sensitivity was evaluated using a brief-access test on day 7.
  • Platinum content in lingual tissues was measured.
  • Tongue cooling during administration was tested as a mitigation strategy.

Main Results:

  • Both liposomal oxaliplatin and oxaliplatin decreased sweet taste sensitivity, with liposomal oxaliplatin causing a greater reduction.
  • Liposomalization increased platinum accumulation in lingual non-epithelial tissues.
  • Tongue cooling during administration reduced lingual platinum accumulation for both formulations.

Conclusions:

  • Liposomal oxaliplatin exacerbates oxaliplatin-induced sweet taste loss by increasing platinum accumulation in the tongue.
  • Reducing liposomal oxaliplatin distribution to the tongue via cooling may preserve taste sensitivity.
  • These findings could improve patient quality of life during chemotherapy.