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Navigation using global or local reference frames in rats with medial and lateral entorhinal cortex lesions.

Julien Poitreau1, Manon Buttet1, Christine Manrique1

  • 1Laboratory of Cognitive Neuroscience, Marseille, France.

Behavioural Brain Research
|July 11, 2021
PubMed
Summary

The medial entorhinal cortex (MEC) is crucial for spatial navigation using global cues. However, neither the MEC nor the lateral entorhinal cortex (LEC) is necessary for local cue-based navigation.

Keywords:
Lateral entorhinal cortexMedial entorhinal cortexRatSpatial cognitionSpatial navigation

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Behavioral Neuroscience

Background:

  • The medial (MEC) and lateral (LEC) entorhinal cortex regions are key inputs to the hippocampus, vital for episodic memory.
  • Recent theories suggest MEC processes global reference frames and LEC processes local reference frames.
  • The role of these regions in navigation contexts remains unclear.

Purpose of the Study:

  • To investigate the distinct roles of the MEC and LEC in spatial navigation using global versus local cues.
  • To determine if MEC and LEC functions in reference frame processing generalize to navigation tasks.

Main Methods:

  • Rats with NMDA-induced MEC or LEC lesions were trained in a water maze navigation task.
  • Two conditions were used: global cues (distal room cues) and local cues (objects in the pool).
  • Performance was assessed during acquisition and probe trials, with object identity manipulated.

Main Results:

  • MEC-lesioned rats showed impaired acquisition and localization in the global cue condition.
  • LEC-lesioned rats performed similarly to controls in the global cue condition.
  • Navigational abilities were unaffected in both lesion groups under the local cue condition.
  • Object identity did not influence navigation accuracy, indicating place navigation is object-identity independent.

Conclusions:

  • The MEC is essential for place navigation that relies on a global reference frame.
  • Navigation utilizing a local reference frame does not require the MEC or LEC.
  • These findings differentiate the roles of MEC and LEC in spatial memory and navigation.