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Nrg1 haploinsufficiency alters inhibitory cortical circuits

Carmen Navarro-Gonzalez1, Héctor Carceller1, Marina Benito Vicente2

  • 1Lab of Cortical Circuits in Health and Disease, CIPF Centro de Investigación Príncipe Felipe, Valencia, Spain.

Neurobiology of Disease
|July 11, 2021
PubMed
Summary

Neuregulin 1 (NRG1) haploinsufficiency impairs inhibitory cortical circuits, leading to schizophrenia-like behaviors. This study reveals synaptic and molecular changes in a novel mouse model, differentiating it from ErbB4 deletions.

Keywords:
Cortical neuronsInhibitory neurotransmissionMagnetic resonance spectroscopyNrg1Schizophrenia

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