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Updated: Oct 29, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Ten picrotoxane-type sesquiterpenoids from the stems of Dendrobium wardianum Warner
Wei-Wei Fan1, Dan Yang2, Zhong-Quan Cheng3
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; Henan Engineering Research Center of Funiu Mountain's Medicinal Resources Utilization and Molecular Medicine, College of Medicine, Pingdingshan University, Pingdingshan, 467000, People's Republic of China.
Abstract:
Ten undescribed picrotoxane-type sesquiterpenoids, dendrowardins A-J, together with two known ones, were isolated from the stems of Dendrobium wardianum Warner (Orchidaceae). Dendrowardins A-D feature the unusual 5,2-δ-lactone and additionally dendrowardins C-D are the first examples containing the 11,10-γ-lactone moiety. The structures were established using spectroscopic methods and by comparison with literature data. Further, dendrowardin E, amotin, and aduncin exhibited significant effects of promoting the proliferation on human lens epithelial cells (HLECs) induced by D-galactose.
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