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Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data
Marianne Meaidi1, Henrik Støvring2, Klaus Rostgaard3
1Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100, København Ø, Denmark.
European Journal of Clinical Pharmacology
|July 11, 2021
Summary
Defining drug exposure duration is complex in pharmacoepidemiology. This review presents methods for assessing prescription redemption and temporal sequences, offering guidance to minimize research bias.
Area of Science:
- Pharmacoepidemiology
- Drug utilization research
Background:
- Accurate definition of drug exposure periods is critical in pharmacoepidemiology.
- Missing or incomplete treatment duration data presents a significant challenge.
Purpose of the Study:
- To review methods for defining pharmacological treatment exposure using secondary data.
- To guide researchers in selecting appropriate methods for their specific study.
Main Methods:
- Review of existing methodologies for defining drug exposure.
- Description of techniques for assessing prescription redemption durations.
- Explanation of methods for creating temporal sequences of drug use.
Main Results:
- Multiple methods exist for assessing prescription redemption and temporal sequencing.
- Awareness of method potentials and pitfalls can minimize research bias.
- No single method is universally applicable.
Conclusions:
- The choice of method should align with the research scenario and applicability.
- Careful consideration of method limitations is essential for robust pharmacoepidemiological studies.
- Guidance is provided to aid researchers in navigating these complex methodological choices.
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