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HIF-1: structure, biology and natural modulators.

Chao Yang1, Zhang-Feng Zhong2, Sheng-Peng Wang2

  • 1National Engineering Research Center for Marine Aquaculture, Institute of Innovation and Application, Zhejiang Ocean University, Zhoushan 316022, China; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

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PubMed
Summary

Hypoxia-inducible factor 1 (HIF-1) regulates cellular responses to low oxygen and is linked to numerous diseases. This review details HIF-1 mechanisms, roles in disease, and potential inhibitor development for therapeutic insights.

Keywords:
Human diseaseHypoxiaInhibitorNatural product

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Physiology

Background:

  • Hypoxia-inducible factor 1 (HIF-1) is a key transcriptional regulator mediating cellular adaptation to oxygen levels.
  • HIF-1 plays critical roles in various physiological and pathological processes.
  • Dysregulation of HIF-1 is implicated in the pathogenesis of numerous human diseases.

Purpose of the Study:

  • To review the activation mechanisms and signaling pathways of HIF-1.
  • To discuss the known natural inhibitors of HIF-1.
  • To explore the multifaceted roles of HIF-1 in human diseases and recent advancements in HIF-1 inhibitor development.

Main Methods:

  • Literature review of scientific articles on HIF-1.
  • Analysis of HIF-1 activation and signaling pathways.
  • Synthesis of information on HIF-1's role in disease pathogenesis and therapeutic strategies.

Main Results:

  • HIF-1 activation is a complex process involving oxygen-dependent and independent pathways.
  • HIF-1 signaling influences diverse cellular functions, impacting disease progression.
  • Natural compounds and synthetic molecules show potential as HIF-1 inhibitors.

Conclusions:

  • Understanding HIF-1 mechanisms offers valuable insights into disease diagnosis and treatment.
  • Targeting HIF-1 presents a promising therapeutic avenue for various human diseases.
  • Continued research into HIF-1 inhibitors is crucial for clinical applications.