Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America...

Area of Science:

• Neuroscience
• Neurology
• Genetics

Background:

• Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder affecting behavior, executive function, and language.
• Current FTD diagnosis relies on clinical expertise and neuroimaging, often leading to underdiagnosis or misdiagnosis due to low correlation with neuropathology.
• Biomarkers show promise for improving FTD diagnosis, but most studies lack representation from the Latin American and Caribbean (LAC) region.

Approach:

• This systematic review provides an overview of current knowledge on genetic, neuroimaging, and fluid biomarkers for FTD in LAC countries.
• It highlights the challenges specific to the LAC region, including limited awareness, complex genetic heritage, and cultural influences.
• The review emphasizes the need for more research in FTD biomarkers within the LAC region.

Key Points:

• FTD diagnosis is complex, with significant challenges in accurate and early detection.
• Biomarker research is crucial for complementing clinical diagnosis in FTD.
• The LAC region presents unique hurdles for FTD biomarker studies, necessitating region-specific research.

Conclusions:

• There is a critical need for extensive research on FTD biomarkers in the LAC region.
• Harmonized, cross-regional studies are essential for a global perspective on dementia research.
• Improving FTD diagnosis in LAC requires addressing regional challenges and fostering collaborative research efforts.