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Dyslipidemia Is Related to Mortality in Critical Patients With Coronavirus Disease 2019: A Retrospective Study

Jiang Yue1, Hua Xu1, Yong Zhou2

  • 1Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Frontiers in Endocrinology
|July 12, 2021
PubMed

Insights

Lipid metabolic disorders are present in critical COVID-19 patients. Lower high-density lipoprotein cholesterol (HDL-c) and total cholesterol (TC) levels are linked to disease progression and mortality in these patients.

Area of Science:

  • Biochemistry
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Dyslipidemia has been linked to coronavirus-related diseases.
  • Critical coronavirus disease 2019 (COVID-19) patients with multiple organ dysfunctions were admitted to the ICU.
  • The association between lipid profiles and prognosis in critical COVID-19 patients was unclear.

Purpose of the Study:

  • To investigate the association between lipid profiles and prognosis in critical COVID-19 patients.
  • To identify potential lipid biomarkers for COVID-19 severity.

Main Methods:

  • A retrospective study of 48 critical COVID-19 patients in Wuhan.
  • Collected lipid profiles, liver function, and renal function parameters on admission, at 2-3 days post-admission, and before clinical outcome.
  • Utilized logistic regression to analyze associations with mortality.

Main Results:

  • Albumin and creatine kinase levels decreased significantly post-admission.
  • Low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), apolipoprotein A (ApoA), and apolipoprotein B (ApoB) levels decreased after admission.
  • Lower HDL-c levels on admission and before outcome were negatively associated with mortality.
  • Total cholesterol (TC) levels at 2-3 days post-admission were related to mortality.

Conclusions:

  • Critical COVID-19 patients exhibit lipid metabolic disorders.
  • Lower HDL-c and TC levels correlate with disease progression and mortality in critical COVID-19.
  • Lipid profiles may serve as prognostic indicators for critical COVID-19 patients.
Abstract

Keywords:
coronavirus disease 2019 (COVID-19)critical patientslipid metabolismmortalityrisk factor

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