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Transurethral Induction of Mouse Urinary Tract Infection
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A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection
Kristian Stærk1, Rasmus Birkholm Grønnemose1, Yaseelan Palarasah2
1Research Unit of Clinical Microbiology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.
Frontiers in Microbiology
|July 12, 2021
Summary
A novel catheter design using a silicone interpenetrating polymer network (IPN) effectively prevents catheter-associated urinary tract infections (CAUTI) by releasing antibacterial agents directly into the bladder.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Medical Devices
Background:
- Catheter-associated urinary tract infection (CAUTI) is a common hospital-acquired infection.
- Current antimicrobial catheter coatings have limitations in preventing infection.
Purpose of the Study:
- To develop and evaluate a novel antimicrobial catheter concept using a silicone-based interpenetrating polymer network (IPN).
- To assess the slow-release prophylaxis of antibacterial agents from the catheter balloon to the urinary bladder.
Main Methods:
- Fabrication of IPN balloon material from silicone tubes using supercritical CO2.
- In vitro and in vivo evaluation of release properties and antibacterial efficacy in a porcine CAUTI model.
- Comparison with Bactiguard Infection Protection (BIP) Foley catheters.
Main Results:
- The IPN catheter concept completely prevented detectable Uropathogenic Escherichia coli in urinary bladders and on catheters.
- Control groups showed significant bacteriuria and catheter-associated biofilm.
- BIP catheters reduced biofilm but did not prevent E. coli bladder colonization.
Conclusions:
- The IPN-catheter concept offers a novel and promising approach for localized treatment of urinary tract infections.
- This technology represents a significant advancement in preventing CAUTI.
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