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EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients
Thomas Luft1, Clemens-Martin Wendtner2, Florentina Kosely3
1Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Frontiers in Immunology
|July 12, 2021
Summary
The Endothelial Activation and Stress Index (EASIX) effectively predicts severe COVID-19 outcomes, including death or mechanical ventilation. This simple tool aids in identifying high-risk patients for closer monitoring during the pandemic.
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- COVID-19, caused by SARS-CoV-2, presents a global health challenge.
- Endothelial cell dysfunction is a key factor in COVID-19's severe progression.
- The Endothelial Activation and Stress Index (EASIX) is a known predictor of complications in other conditions.
Purpose of the Study:
- To evaluate EASIX as a predictor of severe outcomes in COVID-19 patients.
- To determine if EASIX can identify patients requiring intensive surveillance.
- To validate EASIX's prognostic capability in a diverse patient cohort.
Main Methods:
- Prospective study of 100 hospitalized SARS-CoV-2-positive patients.
- Assessment of EASIX and other biomarkers at hospital admission.
- Validation in an independent cohort of 126 patients.
Main Results:
- EASIX strongly predicted severe COVID-19 (mechanical ventilation/death) and mortality.
- EASIX remained a significant predictor after adjusting for clinical factors.
- EASIX correlated with specific inflammatory and endothelial markers.
Conclusions:
- EASIX is a validated prognostic tool for COVID-19.
- EASIX facilitates the identification of patients needing intensive monitoring.
- This index offers a practical approach to resource allocation in COVID-19 care.
Keywords:
EASIXSARS-CoV2 (COVID- 19)angiopoietin-2 (Ang-2)endothelial activation and stress indexprediction of outcomesoluble thrombomodulinsuppressor of tumorigenicity 2 (ST2)More Related Videos
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