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Methods and rationale of the DISCOVER CKD global observational study
Roberto Pecoits-Filho1,2, Glen James3, Juan Jesus Carrero4
1School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Clinical Kidney Journal
|July 12, 2021
Summary
Limited real-world data on chronic kidney disease (CKD) impacts patient care. The DISCOVER CKD study addresses this by collecting comprehensive data to improve understanding and management of CKD globally.
Area of Science:
- Nephrology and Epidemiology
- Real-world evidence generation
Background:
- Limited real-world data exists for chronic kidney disease (CKD) patients regarding clinical management, metabolic control, quality of life (QoL), and dietary habits.
- Understanding these gaps is crucial for improving patient prognosis and management.
Purpose of the Study:
- To gather comprehensive real-world data on chronic kidney disease (CKD) patients.
- To identify challenges, consequences, and determinants of outcomes in CKD management.
- To inform clinical practice and improve patient care globally.
Main Methods:
- An enriched hybrid study design incorporating retrospective and prospective cohorts.
- Integration of primary and secondary data from over 1000 CKD patients across multiple countries over 3 years.
- Utilizing electronic case report forms, mobile applications for patient-reported outcomes (PROs), and in-depth interviews.
Main Results:
- The program captures extensive patient data including demographics, biomarkers, medical history, clinical outcomes, and healthcare resource utilization.
- Detailed information on medications, dietary patterns, physical activity, and patient-reported outcomes (PROs) including quality of life (QoL) will be reported.
- Qualitative insights from patient interviews will supplement quantitative data.
Conclusions:
- The DISCOVER CKD program will offer contemporary real-world insights into the epidemiology and burden of CKD.
- Findings will inform clinical practice and enhance understanding of factors influencing clinical outcomes and PROs.
- This study provides a global perspective on managing chronic kidney disease in routine care settings.
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