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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Central catecholaminergic blockade with clonidine prevent SARS-CoV-2 complication: A case series
Sanjiv K Hyoju1, Bidur Baral2, Prabin K Jha3
1Bhomi Hospital and Institute of Medical Sciences, Banepa, Nepal.
Idcases
|July 12, 2021
Summary
Clonidine may help manage severe COVID-19 by modulating the inflammatory response. This case series suggests clonidine
Area of Science:
- Infectious Diseases
- Pharmacology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes life-threatening COVID-19, characterized by rapid respiratory failure and inflammation.
- The catecholaminergic response is implicated in the rapid clinical deterioration and cytokine storm associated with severe COVID-19.
Observation:
- Three male patients in Kathmandu Valley with severe COVID-19 pneumonia were treated with clonidine.
- One patient received oral clonidine at home, while two hospitalized patients received clonidine with supplemental oxygen.
Findings:
- All three patients with severe COVID-19 pneumonia experienced complete recovery.
- Clonidine administration appeared to modulate the acute inflammatory consequences of SARS-CoV-2 infection.
Implications:
- Early clonidine administration may offer a therapeutic strategy to mitigate the severe inflammatory response in COVID-19.
- Further research is warranted to explore clonidine's role in managing SARS-CoV-2 infection and its associated hyperinflammatory state.
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