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Updated: Oct 29, 2025

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Published on: September 30, 2021
Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects
Xinrong Lin1, Xiaosong Xiang2, Bing Feng1
1Department of Medical Oncology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Long non-coding RNAs (lncRNAs) show abnormal expression in hepatocellular carcinoma, impacting tumor progression and treatment resistance. Targeting lncRNAs offers a promising strategy for improving patient survival in liver cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Hepatocellular carcinoma (HCC) is a major global cancer with poor prognosis.
- Aberrant expression of long non-coding RNAs (lncRNAs) is observed in various cancers, including HCC.
- lncRNAs play critical roles in cellular processes relevant to cancer development.
Conclusions:
- lncRNAs are crucial regulators in hepatocellular carcinoma pathogenesis.
- Targeting lncRNAs presents a promising avenue for novel HCC therapies.
- Understanding lncRNA functions can enhance treatment strategies for liver cancer.
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