Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.8K
Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

31.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.8K
Incomplete Dominance01:43

Incomplete Dominance

28.2K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
28.2K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

8.0K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
8.0K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complimentary Episignature Testing for Variant Reclassification: Case Reports with Variant Classification Guideline Consideration.

Molecular syndromology·2026
Same author

A hybrid DenseNet121-random vector functional link (RVFL) approach for plant leaf classification.

Scientific reports·2026
Same author

Clinical, biochemical and molecular spectrum of acute neuronopathic type 2 Gaucher disease from India.

BMC pediatrics·2026
Same author

Prepubertal Initiation of Imatinib is Associated with Reduced Final Height in Children with Chronic Myeloid Leukemia.

Pediatric hematology and oncology·2026
Same author

Impact of Juvenile Dermatomyositis on Growth, Puberty, Bone Mineral Density, and Body Composition in Children.

Mediterranean journal of rheumatology·2026
Same author

Quantitative proteomic profiling of placental extracellular vesicles in recurrent pregnancy loss reveals their role in feto-maternal crosstalk.

BMC pregnancy and childbirth·2026

Related Experiment Video

Updated: Oct 29, 2025

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
12:49

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Published on: September 4, 2011

14.1K

Epigenetics in Kawasaki Disease.

Kaushal Sharma1, Pandiarajan Vignesh1, Priyanka Srivastava1

  • 1Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Frontiers in Pediatrics
|July 12, 2021
PubMed
Summary

Epigenetic factors like methylation and micro-RNAs may explain Kawasaki disease (KD) causes. Analyzing these epigenetic mechanisms can lead to better KD diagnosis and targeted treatments.

Keywords:
Kawasaki diseasebiomarkerlong non-coding RNAmethylationmicroRNA

More Related Videos

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.2K
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.9K

Related Experiment Videos

Last Updated: Oct 29, 2025

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
12:49

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Published on: September 4, 2011

14.1K
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

8.2K
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.9K

Area of Science:

  • Pediatric rheumatology
  • Immunology
  • Genetics

Background:

  • Kawasaki disease (KD) is a critical pediatric illness causing coronary artery inflammation and potential long-term cardiac issues.
  • Genetic predisposition is suggested by familial and ethnic patterns, but environmental triggers like infections are also implicated.
  • The interplay between genetic susceptibility and environmental factors in KD pathogenesis remains unclear.

Purpose of the Study:

  • To review the role of epigenetic mechanisms in Kawasaki disease.
  • To explore how epigenetic factors like DNA methylation, micro-RNAs, and long non-coding RNAs contribute to KD.
  • To discuss the potential of epigenetics in developing diagnostic biomarkers and targeted therapies for KD.

Main Methods:

  • Comprehensive literature review of studies on epigenetic factors in Kawasaki disease.
  • Analysis of research on DNA methylation, micro-RNAs (miRNAs), and long non-coding RNAs (lncRNAs) in KD.
  • Synthesis of findings to understand the link between epigenetics, KD pathogenesis, and clinical applications.

Main Results:

  • Epigenetic modifications, including DNA methylation and non-coding RNAs, are implicated in KD development.
  • These epigenetic factors offer a plausible mechanism connecting genetic predisposition and environmental triggers in KD.
  • Epigenetic alterations show potential as biomarkers for KD diagnosis and prognosis.

Conclusions:

  • Epigenetic mechanisms are crucial in understanding Kawasaki disease pathogenesis.
  • Further research into epigenetic factors can pave the way for novel diagnostic tools and personalized treatment strategies for KD.
  • Epigenetic insights may advance pharmacogenomics for more effective KD therapies.