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Related Experiment Video

Updated: Oct 29, 2025

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array
07:19

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Engineering microenvironments for manufacturing therapeutic cells.

Brian J Kwee1, Kyung E Sung1

  • 1Division of Cellular and Gene Therapies, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20903, USA.

Experimental Biology and Medicine (Maywood, N.J.)
|July 12, 2021
PubMed
Summary
This summary is machine-generated.

Manufacturing therapeutic cells for regenerative medicine and immunotherapies can be improved. Biomaterials, bioreactors, and microphysiological systems offer strategies to enhance cell expansion, characterization, and quality for better therapeutic outcomes.

Keywords:
Cell and gene therapiesbiomaterialsbioreactorscell manufacturingmicrophysiological systems

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Increasing use of autologous and allogeneic therapeutic cells in regenerative medicine and immunotherapies.
  • Need for rapid, cost-effective cell manufacturing methods.
  • Cellular heterogeneity can lead to variable therapeutic outcomes.

Purpose of the Study:

  • To review engineering strategies for enhancing therapeutic cell expansion and characterization.
  • To explore the use of biomaterials, bioreactors, and microphysiological systems.
  • To improve the quality and consistency of cell-based products.

Main Methods:

  • Review of engineering approaches for cell expansion using biomaterials and bioreactors.
  • Discussion of microphysiological systems for cell product characterization.
  • Focus on providing microenvironmental cues to cells.

Main Results:

  • Biomaterials and bioreactors can enhance therapeutic cell expansion.
  • Microphysiological systems allow for evaluation in physiologically relevant conditions.
  • Engineering strategies can maintain cell quality attributes and function.

Conclusions:

  • Biomaterial and bioreactor engineering can improve therapeutic cell manufacturing.
  • Microphysiological systems are valuable tools for cell product characterization and quality control.
  • These approaches hold promise for optimizing cell therapies.