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Expanding Germline Testing to All Patients With Esophagogastric Cancers-Easy to Do, Harder to Justify

Thomas L Holden1, Catherine Neumann2, Michael J Hall2

  • 1Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

JAMA Network Open
|July 12, 2021
PubMed
Abstract

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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