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Updated: Jul 9, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
[Nonaccidental traumatic brain injury in infants and children]
W Reith1, M Kettner2, U Yilmaz2
1Klinik für Diagnostische, und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66424, Homburg-Saar, Deutschland. Wolfgang.Reith@uniklinikum-saarland.de.
Insights
Violent traumatic brain injury (TBI) in children, often caused by nonaccidental shaking, leads to severe brain damage and potential long-term disabilities. Education on the dangers of shaking trauma is crucial for prevention.
Area of Science:
- Pediatrics
- Neurology
- Forensic Medicine
Background:
- Violent traumatic brain injury (TBI) is a significant cause of childhood mortality globally.
- Nonaccidental trauma accounts for approximately 20% of TBI in children under two years old.
- Shaken impact syndrome results from violent shaking, causing severe brain and spinal cord injury.
Purpose of the Study:
- To highlight the mechanisms and consequences of nonaccidental TBI in children.
- To emphasize the severe clinical manifestations and long-term effects of shaken impact syndrome.
- To advocate for preventive measures, particularly educational interventions.
Main Methods:
- Review of clinical presentations and pathological findings associated with violent TBI in pediatric populations.
- Analysis of injury patterns, including vascular rupture, axonal shear injuries, and associated fractures.
- Correlation of clinical symptoms with increased intracranial pressure and brain stem involvement.
Main Results:
- Violent TBI can cause bridge vein rupture, axonal shear injuries, and brain swelling.
- Brain stem involvement may lead to respiratory arrest; symptoms include poor feeding, seizures, and vomiting.
- Long-term consequences encompass neurological, neuropsychological, visual, and auditory deficits, alongside poor academic performance.
Conclusions:
- Nonaccidental TBI, particularly shaken impact syndrome, carries a poor prognosis.
- Early recognition of symptoms like seizures, vomiting, and altered consciousness is critical.
- Preventive strategies, focusing on educating caregivers about the dangers of shaking, are essential.
Abstract:
Violent traumatic brain injury (TBI) can cause brain dysfunction and injury. Accidental and nonaccidental trauma are still the leading cause of childhood death worldwide. It is assumed that about 20% of TBI in children under 2 years of age are nonaccidentally caused. In all cases, nonaccidental TBI is caused by the violent impact on the brain and spinal cord by the massive shaking of the child held by the upper arms or body. This can lead to a rupture of blood vessels, especially bridge veins, as well as axonal shear injuries to the nerve connections and brain swelling. Involvement of the brain stem can lead to initial short-term respiratory arrest. The resulting clinical symptoms include poor drinking, drowsiness, apathy, cerebral seizures, breathing disorders, temperature disorders, and vomiting as a result of increased intracranial pressure. Long-term disorders can include neurological and neuropsychological disorders, hearing disorders, visual disorders up to blindness, and poor school performance. In addition, there are metaphyseal fractures and rib fractures of various forms, also of different ages. Since shaking trauma has a poor prognosis, preventive measures are useful: education!
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