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NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways

Yujun Li1,2, Junrong Liang3, Hui Dang1

  • 1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.

Endocrine
|July 12, 2021
PubMed
Abstract

Insights

Nuclear Receptor Coactivator 3 (NCOA3) is upregulated in thyroid cancer, promoting cell proliferation and invasion. Targeting NCOA3 may offer a new therapeutic strategy for thyroid cancer treatment.

Area of Science:

  • Molecular Oncology
  • Cancer Biology
  • Endocrinology

Background:

  • Nuclear Receptor Coactivator 3 (NCOA3), also known as SRC-3, is an oncogene implicated in various cancers.
  • The specific role of NCOA3 in the development and progression of thyroid cancer has not been fully elucidated.
  • Understanding NCOA3's function is crucial for identifying potential therapeutic targets in thyroid malignancies.

Purpose of the Study:

  • To investigate the biological function and clinical significance of NCOA3 in thyroid cancer.
  • To determine if NCOA3 expression levels correlate with thyroid cancer development.
  • To explore the potential of NCOA3 as a therapeutic target or prognostic marker for thyroid cancer.

Main Methods:

  • Assessed NCOA3 mRNA and protein expression in thyroid cancer tissues versus matched non-cancerous tissues.
  • Evaluated the impact of NCOA3 knockdown and ectopic expression on thyroid cancer cell malignant activities (proliferation, invasion, cell cycle, apoptosis).
  • Investigated the molecular pathways modulated by NCOA3 in thyroid cancer cells, including ErbB, AKT, ERK, and β-catenin signaling.

Main Results:

  • NCOA3 protein expression was significantly elevated in thyroid cancer tissues compared to normal tissues.
  • NCOA3 knockdown suppressed thyroid cancer cell proliferation and invasion while inducing cell cycle arrest and apoptosis.
  • Ectopic NCOA3 expression enhanced thyroid cancer cell proliferation and invasiveness, mediated by the ErbB, AKT, ERK, and β-catenin pathways.

Conclusions:

  • NCOA3 plays a critical role in the initiation and progression of thyroid cancer.
  • NCOA3 promotes thyroid cancer cell survival and invasiveness through key signaling pathways.
  • NCOA3 represents a potential prognostic biomarker and therapeutic target for thyroid cancer.
Keywords:
AKTERKErbBNCOA3Thyroid cancer

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