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The polymorphic pattern of somatomedins during human development.

W F Blum1, M B Ranke, B Lechner

  • 1University Children's Hospital, Tübingen, FRG.

Acta Endocrinologica
|December 1, 1987
PubMed
Summary
This summary is machine-generated.

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Human somatomedins exhibit heterogeneity, with distinct patterns for insulin-like growth factor I/Sm-C and IGF-II families. These polymorphic profiles remain stable throughout development in healthy individuals.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Background:

  • Human somatomedins (Sm) display heterogeneity upon chromatofocusing.
  • Beyond classic insulin-like growth factors (IGF-I/Sm-C and IGF-II), minor somatomedin-like peaks exist.

Purpose of the Study:

  • To determine if somatomedin polymorphism is present within individuals.
  • To investigate developmental changes in somatomedin polymorphic patterns.

Main Methods:

  • Serum extracts from healthy children and adults were analyzed.
  • Chromatofocusing was used to fractionate somatomedin-like peptides.
  • Specific radioimmunoassays quantified IGF-I/Sm-C and IGF-II levels.

Main Results:

Related Experiment Videos

  • Somatomedin heterogeneity is a common finding across all individuals studied.
  • Polymorphic patterns for IGF-I/Sm-C and IGF-II families showed stability during development.
  • Minor variations in polymorphic patterns were observed during development.

    • Conclusions:

    • Somatomedin heterogeneity is a consistent characteristic in humans.
    • The established polymorphic profiles of IGF-I/Sm-C and IGF-II families are largely conserved throughout human development.