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Pyroptosis, a new bridge to tumor immunity
Lisha Li1, Mingxia Jiang1, Ling Qi1
1Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Cancer Science
|July 12, 2021
Summary
Pyroptosis, a form of programmed cell death, plays a dual role in cancer immunity. It can promote tumor growth by evading immune surveillance but also enhance cancer immunotherapies by recruiting immune cells.
Area of Science:
- Immunology
- Cell Biology
- Oncology
Background:
- Pyroptosis is gasdermin (GSDM)-mediated programmed cell death (PCD) with known extracellular responses.
- Emerging evidence highlights pyroptosis's role in immune system activation and cancer therapy.
Purpose of the Study:
- To review the dual role of pyroptosis-induced immune responses in tumorigenesis.
- To discuss pyroptosis's interplay with the immune system and its potential as a therapeutic target.
Main Methods:
- Literature review of pyroptosis mechanisms and immune responses in cancer.
- Analysis of pyroptosis's impact on tumor microenvironment and immunotherapy.
Main Results:
- Pyroptosis activation can promote tumors by altering the immune microenvironment and evading surveillance.
- Pyroptosis-induced cytokines can enhance anti-tumor immunity and improve immunotherapy efficacy.
Conclusions:
- The immune response to pyroptosis is a double-edged sword in cancer development.
- Targeting pyroptosis holds promise for novel cancer immunotherapies, potentially in combination with immune checkpoint inhibitors like PD-1/PD-L1.
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