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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
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Thrombotic microangiopathy during pregnancy
Sepideh Zununi Vahed1, Yalda Rahbar Saadat1, Mohammadreza Ardalan1
1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Microvascular Research
|July 12, 2021
Summary
Pregnancy poses a high risk for thrombotic microangiopathy (TMA). This review covers diagnosis and management of TTP, PE/HELLP, and aHUS during pregnancy, despite diagnostic challenges.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Nephrology
Background:
- Pregnancy is a period of increased risk for thrombotic microangiopathy (TMA).
- Key pregnancy-related TMAs include thrombotic thrombocytopenic purpura (TTP), preeclampsia/hemolysis, elevated liver function tests, low platelets (HELLP), and atypical hemolytic-uremic syndrome (aHUS).
- These conditions share overlapping clinical features and can involve multiple pathological mechanisms.
Purpose of the Study:
- To review current knowledge on the diagnosis and management of TMA during pregnancy.
- To highlight diagnostic and therapeutic challenges associated with pregnancy-related TMA.
Main Methods:
- Literature review focusing on diagnostic criteria and therapeutic strategies for TTP, PE/HELLP, and aHUS in pregnancy.
- Synthesis of current understanding of pathophysiology and clinical presentation.
Main Results:
- Pregnancy-associated TMAs result in endothelial damage and microvascular fibrin thrombi.
- These disorders lead to red blood cell fragmentation (schistocytes), platelet aggregation, and ischemic injury in organs like the kidneys and brain.
- Despite revealed mechanisms, diagnosis and management remain challenging.
Conclusions:
- Early recognition and appropriate management of TTP, PE/HELLP, and aHUS are crucial in pregnancy.
- Addressing diagnostic and therapeutic complexities is essential for improving outcomes in pregnancy-related TMA.
Keywords:
Atypical hemolytic uremic syndromeMicroangiopathyPre-eclampsiaPregnancyPurpura, thrombotic thrombocytopenicMore Related Videos
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