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The prognostic significance of virus-associated changes in grade 1 cervical intra-epithelial neoplasia
P Bagi1, A M Worning, M Nordsten
1Department of Obstetrics and Gynecology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Abstract:
Virus-associated changes of the cervix uteri were assessed in patients treated for grade 1 cervical intra-epithelial neoplasia (CIN). Of 106 patients evaluated, 67 (63%) had virus-associated changes. The patients were treated without regard to the presence/absence of virus-associated changes. In 26 patients the treatment was unsuccessful (persistence, recurrence, or progression of the neoplasia). The frequency of treatment failure was 33% in patients with, and 10% in patients without virus-associated changes (p less than 0.025). It is recommended that patients with CIN 1 and virus-associated changes should, after initial treatment, be followed-up with increased attention.