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Updated: Oct 29, 2025

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
Brainstem stroke presenting as isolated bilateral ptosis
Sunil James1, Karunakaran Pradeep Thozhuthumparambil2
1Department of Acute Internal Medicine, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK sunil.james1@nhs.net.
Abstract:
Pure midbrain infarctions not involving surrounding structures are an uncommon clinical phenomenon. A midbrain infarction that results in isolated bilateral ptosis as the only neurological deficit is much rarer and an easy diagnosis to miss; therefore, potentially leading to further downstream complications. We describe the case of an elderly patient who presented with isolated bilateral ptosis, initially thought to be consequent to myasthenia gravis but subsequently identified to have a perforator infarct in the midbrain, resulting in his symptoms.
Insights
Isolated bilateral ptosis can signal a rare midbrain infarction. Prompt diagnosis of this uncommon neurological deficit is crucial to prevent complications.
Area of Science:
- Neurology
- Neuroscience
- Clinical Medicine
Background:
- Pure midbrain infarctions are rare neurological events.
- Isolated bilateral ptosis as the sole symptom is exceptionally uncommon.
Observation:
- An elderly patient presented with isolated bilateral ptosis.
- The initial diagnosis considered myasthenia gravis.
Findings:
- The patient was diagnosed with a perforator infarct in the midbrain.
- The midbrain infarct was the cause of the isolated bilateral ptosis.
Implications:
- Highlights the importance of considering midbrain infarcts in cases of isolated ptosis.
- Early identification of this rare condition is key to appropriate management.
- Undiagnosed midbrain lesions can lead to significant downstream complications.
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