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Stromal cell interplay in prostate development, physiology, and pathological conditions.

Bruno D A Sanches1, Juliana S Maldarine1, Patricia S L Vilamaior2

  • 1Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil.

The Prostate
|July 13, 2021
PubMed
Summary

Prostate stroma supports gland function and development. It plays a role in prostate cancer and involves stromal cells, including telocytes, in organization and signaling.

Keywords:
CD34castrationhormonal metabolismparacrine signalingreactive stromasenescencesmooth muscle cellsstem cellstelocytestissue organization

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Area of Science:

  • Urology
  • Cell Biology
  • Cancer Biology

Background:

  • Prostate stroma supports secretory epithelium and is crucial for gland morphogenesis, hormonal metabolism, and function.
  • The stroma is implicated in prostate cancer development, forming a reactive microenvironment that promotes tumorigenesis.
  • Prostatic stromal cells communicate via paracrine signaling in a hormone-sensitive gland.

Purpose of the Study:

  • To review current understanding of prostate stromal cells.
  • To explore the interrelationships between different prostate stromal cell types.
  • To discuss the implications of stromal cells in prostate development, physiology, and pathology.

Main Methods:

  • Literature review of recent advances in prostate stroma research.
  • Analysis of studies on stromal cell types, including telocytes.
  • Synthesis of information on stromal cell interactions and signaling.

Main Results:

  • Prostate stroma is essential for epithelial function and gland development.
  • Reactive stroma contributes to prostate cancer progression.
  • Telocytes are identified as key players in prostate stromal organization and cell communication.

Conclusions:

  • Understanding prostate stromal cell types and their interactions is vital for comprehending prostate health and disease.
  • Telocytes represent a significant component of the prostate stroma, influencing its structure and function.
  • Further research into prostate stroma biology may reveal new therapeutic targets for prostate cancer.