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A New Call to Action to Combat an Old Nemesis: Addressing Rising Congenital Syphilis Rates in the United States
Aliza M Machefsky1,2, Penny S Loosier1, Ryan Cramer1
1Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Insights
Congenital syphilis (CS) is increasing, posing a public health risk. Early identification and treatment of maternal syphilis with penicillin G during pregnancy can prevent infant infections and complications.
Area of Science:
- Public Health
- Infectious Diseases
- Maternal-Fetal Medicine
Background:
- Congenital syphilis (CS) is a growing public health concern in the United States.
- It results from transplacental transmission of *Treponema pallidum* from an infected pregnant woman to her fetus.
- Untreated maternal syphilis can lead to adverse pregnancy outcomes and severe health issues in newborns.
Purpose of the Study:
- To discuss challenges in preventing congenital syphilis.
- To summarize missed opportunities for CS prevention.
- To provide practical solutions for future CS prevention strategies.
Main Methods:
- Review of public health and healthcare system challenges.
- Analysis of missed opportunities in CS prevention.
- Development of practical solutions for CS prevention.
Main Results:
- Congenital syphilis is a preventable infection.
- Effective prevention relies on timely identification and treatment of maternal syphilis.
- Challenges exist in current public health and healthcare systems for CS prevention.
Conclusions:
- Timely and appropriate penicillin G treatment during pregnancy is crucial for preventing CS.
- Addressing system-level challenges and missed opportunities is vital for future CS prevention.
- Enhanced strategies are needed to combat the rise of congenital syphilis.
Abstract:
Congenital syphilis (CS) is on the rise in the United States and is a growing public health concern. CS is an infection with Treponema pallidum in an infant or fetus, acquired via transplacental transmission when a pregnant woman has untreated or inadequately treated syphilis. Pregnant women with untreated syphilis are more likely to experience pregnancies complicated by stillbirth, prematurity, low birth weight, and early infant death, while their children can develop clinical manifestations of CS such as hepatosplenomegaly, bone abnormalities, developmental delays, and hearing loss. One of the ways CS can be prevented is by identifying and treating infected women during pregnancy with a benzathine penicillin G regimen that is both appropriate for the maternal stage of syphilis and initiated at least 30 days prior to delivery. In this article we discuss many of the challenges faced by both public health and healthcare systems with regards to this preventable infection, summarize missed opportunities for CS prevention, and provide practical solutions for future CS prevention strategies.
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